Title
Reduced energy intake : the secret to a long and healthy life? Reduced energy intake : the secret to a long and healthy life?
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
IBS Journal of Science
Volume/pages
2(2007) :2 , p. 35-39
ISSN
1751-0724
Carrier
E
Target language
English (eng)
Abstract
Reduced energy intake, or caloric restriction (CR), is known to extend life-span and to retard agerelated health decline in a myriad of species, including nematode worms, flies, fish, mice and rats. The exact mechanism whereby CR exerts its life-extending and health-extending effects is unclear. CR however has been shown to improve insulin sensitivity, reduce oxidative stress and alter neuroendocrine responses and central nervous system (CNS) function in animals. In this review article we provide a comprehensive overview of the effects of CR on animal physiology and we discuss some of the potential molecular mechanisms and pathways whereby reduced energy intake can increase health-span and life-span. A better understanding of how energy intake can influence the aging process could lead to new strategies and therapeutics to reduce age-related decline and increase health-span.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/5e4114/132158.pdf