Publication
Title
Reduced energy intake : the secret to a long and healthy life?
Author
Abstract
Reduced energy intake, or caloric restriction (CR), is known to extend life-span and to retard agerelated health decline in a myriad of species, including nematode worms, flies, fish, mice and rats. The exact mechanism whereby CR exerts its life-extending and health-extending effects is unclear. CR however has been shown to improve insulin sensitivity, reduce oxidative stress and alter neuroendocrine responses and central nervous system (CNS) function in animals. In this review article we provide a comprehensive overview of the effects of CR on animal physiology and we discuss some of the potential molecular mechanisms and pathways whereby reduced energy intake can increase health-span and life-span. A better understanding of how energy intake can influence the aging process could lead to new strategies and therapeutics to reduce age-related decline and increase health-span.
Language
English
Source (journal)
IBS Journal of Science
Publication
2007
ISSN
1751-0724
Volume/pages
2:2(2007), p. 35-39
Full text (open access)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Record
Identification
Creation 02.04.2016
Last edited 07.04.2016