Title
In vitro antiprotozoal activity of five plant extracts from Albaha region In vitro antiprotozoal activity of five plant extracts from Albaha region
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Subject
Pharmacology. Therapy
Source (journal)
World journal of pharmaceutical research
Volume/pages
5(2016) :3 , p. 338-346
ISSN
2277-7105
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Five methanol extracts obtained from five plant species selected according ethnobotanical data were screened for their antiprotozoal activity against Plasmodium falciparum, Leishmania infantum, Trypanosoma cruzi and Trypanosoma brucei. Cytotoxicity was evaluated on MRC-5 cells. Withania somnifera methanol extract showed low activity against P. falciparum (IC50 17.7 μg ml-1), but with non-selective antimalarial activity. Most of the extracts tested against L. infantum exhibited low activity with IC50 ranging from 20 to 32 μg ml-1, except W. somnifera which showed a remarkable but non-selective leishmanicidal activity (IC50 of 2.0 μg ml-1). W. somnifera methanol extract also exhibited a marked activity against T cruzi (IC50 0.6 μg ml-1, SI=3.5).
Full text (open access)
https://repository.uantwerpen.be/docman/irua/19a7d1/132172.pdf
E-info
https://repository.uantwerpen.be/docman/iruaauth/1add3f/132172.pdf
Handle