Title
A reconfigurable visual-programming library for real-time closed-loop cellular electrophysiology A reconfigurable visual-programming library for real-time closed-loop cellular electrophysiology
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Subject
Mathematics
Biology
Human medicine
Computer. Automation
Source (journal)
Frontiers in neuroinformatics. - -
Volume/pages
9(2015) , 16 p.
ISSN
1662-5196
1662-5196
Article Reference
17
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Most of the software platforms for cellular electrophysiology are limited in terms of flexibility, hardware support, ease of use, or re-configuration and adaptation for non-expert users. Moreover, advanced experimental protocols requiring real-time closed-loop operation to investigate excitability, plasticity, dynamics, are largely inaccessible to users without moderate to substantial computer proficiency. Here we present an approach based on MATLAB/Simulink, exploiting the benefits of LEGO-like visual programming and configuration, combined to a small, but easily extendible library of functional software components. We provide and validate several examples, implementing conventional and more sophisticated experimental protocols such as dynamic-clamp or the combined use of intracellular and extracellular methods, involving closed-loop real-time control. The functionality of each of these examples is demonstrated with relevant experiments. These can be used as a starting point to create and support a larger variety of electrophysiological tools and methods, hopefully extending the range of default techniques and protocols currently employed in experimental labs across the world.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/fb9fbd/132186.pdf
E-info
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Handle