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Title
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A reconfigurable visual-programming library for real-time closed-loop cellular electrophysiology
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Author
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Abstract
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| Most of the software platforms for cellular electrophysiology are limited in terms of flexibility, hardware support, ease of use, or re-configuration and adaptation for non-expert users. Moreover, advanced experimental protocols requiring real-time closed-loop operation to investigate excitability, plasticity, dynamics, are largely inaccessible to users without moderate to substantial computer proficiency. Here we present an approach based on MATLAB/Simulink, exploiting the benefits of LEGO-like visual programming and configuration, combined to a small, but easily extendible library of functional software components. We provide and validate several examples, implementing conventional and more sophisticated experimental protocols such as dynamic-clamp or the combined use of intracellular and extracellular methods, involving closed-loop real-time control. The functionality of each of these examples is demonstrated with relevant experiments. These can be used as a starting point to create and support a larger variety of electrophysiological tools and methods, hopefully extending the range of default techniques and protocols currently employed in experimental labs across the world. |
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Language
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English
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Source (journal)
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Frontiers in neuroinformatics. - -
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Publication
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2015
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ISSN
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1662-5196
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DOI
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10.3389/FNINF.2015.00017
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Volume/pages
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9
(2015)
, 16 p.
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Article Reference
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17
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ISI
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000370606200001
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Pubmed ID
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26157385
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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