Title
Xenobiotic metabolism in the zebrafish : a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1 to 3 Xenobiotic metabolism in the zebrafish : a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1 to 3
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Publication type
article
Publication
Tokyo :Japanese soc toxicological sciences ,
Subject
Pharmacology. Therapy
Veterinary medicine
Source (journal)
Journal of toxicological sciences: official journal of the Japanese Society of Toxicological Sciences. - Wakayama
Journal of toxicological sciences: official journal of the Japanese Society of Toxicological Sciences. - Wakayama
Volume/pages
41(2016) :1 , p. 1-11
ISSN
0388-1350
ISI
000369564800001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The zebrafish (Danio rerio) has been increasingly explored in pharmaceutical research as a promising alternative model for toxicological screens. This necessitates a thorough knowledge on the biotransformation processes for a correct interpretation of pharmacological and toxicological data. Physiologically, cytochrome P450 (CYP) enzymes, specifically CYP families 1-3, play a pivotal role in drug metabolism. And yet, information regarding activity of CYP, its isoforms, and conjugation enzymes in zebrafish is either scarce or conflicting. To account for this discrepancy, the available spatiotemporal, modulation and activity data on zebrafish CYP 1-3 families are reviewed in this paper and compared with human CYP data. The CYP genetic features and synteny are well characterized, as is their expression in different organ systems. Moreover, several substrates metabolized by humans also show metabolism in zebrafish, with other CYP isoforms possibly involved. Altogether, the five CYP1 members, 41 CYP2 members and five CYP3 members in zebrafish show distinct evolutionary and orthological similarities with humans.
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Full text (open access)
https://repository.uantwerpen.be/docman/irua/5e9547/132248.pdf
https://repository.uantwerpen.be/docman/irua/b60d92/130887.pdf
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