Publication
Title
Prevalence of obstructive sleep apnea in children with Down syndrome
Author
Abstract
Study Objectives: To evaluate the prevalence of obstructive sleep apnea (OSA) in a large cohort of children with Down syndrome (DS), and to investigate which patient-related factors correlate with disease severity. Methods: We performed a retrospective, cross-sectional study in children with DS referred for full overnight polysomnography in a tertiary care center. Results: Polysomnographic data are available for 122 children (70 boys), age 5.0 y (2.8-10.5), and body mass index (BMI) z-score 0.7 (-0.3 to 1.7). The overall prevalence of OSA was 66.4%. In almost half of these children severe OSA was diagnosed (obstructive AHI [oAHI] >= 10/h). In children with parental reports of snoring or witnessed apneas (group A), OSA was significantly more common (75.7%) than in those without these symptoms (group B) 53.8% (P = 0.019). Children in group A had more severe OSA, oAHI 5.7/h (1.7-13.8) compared to those in group B 2.2/h (0.8-8.0) (P = 0.018). A significant inverse correlation between age and oAHI (P = 0.028) was found. Sex and BMI z-score were not significantly correlated to oAHI. Conclusions: Based upon full night polysomnography, an overall 66.4% prevalence of OSA was found in children with Down syndrome. Even in those with a negative history for OSA, the prevalence was 53.8%. Younger age was associated with more severe disease.
Language
English
Source (journal)
Sleep. - New York, N.Y., 1978, currens
Publication
New York, N.Y. : 2016
ISSN
0161-8105 [print]
1550-9109 [online]
Volume/pages
39:3(2016), p. 699-704
Article Reference
PII sp-00410-15
ISI
000371115800024
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 05.04.2016
Last edited 10.11.2017
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