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Title
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Prevalence of obstructive sleep apnea in children with Down syndrome
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Author
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Abstract
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| Study Objectives: To evaluate the prevalence of obstructive sleep apnea (OSA) in a large cohort of children with Down syndrome (DS), and to investigate which patient-related factors correlate with disease severity. Methods: We performed a retrospective, cross-sectional study in children with DS referred for full overnight polysomnography in a tertiary care center. Results: Polysomnographic data are available for 122 children (70 boys), age 5.0 y (2.8-10.5), and body mass index (BMI) z-score 0.7 (-0.3 to 1.7). The overall prevalence of OSA was 66.4%. In almost half of these children severe OSA was diagnosed (obstructive AHI [oAHI] >= 10/h). In children with parental reports of snoring or witnessed apneas (group A), OSA was significantly more common (75.7%) than in those without these symptoms (group B) 53.8% (P = 0.019). Children in group A had more severe OSA, oAHI 5.7/h (1.7-13.8) compared to those in group B 2.2/h (0.8-8.0) (P = 0.018). A significant inverse correlation between age and oAHI (P = 0.028) was found. Sex and BMI z-score were not significantly correlated to oAHI. Conclusions: Based upon full night polysomnography, an overall 66.4% prevalence of OSA was found in children with Down syndrome. Even in those with a negative history for OSA, the prevalence was 53.8%. Younger age was associated with more severe disease. |
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Language
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English
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Source (journal)
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Sleep. - New York, N.Y., 1978, currens
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Publication
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New York, N.Y.
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2016
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ISSN
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0161-8105
[print]
1550-9109
[online]
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DOI
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10.5665/SLEEP.5554
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Volume/pages
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39
:3
(2016)
, p. 699-704
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Article Reference
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PII sp-00410-15
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ISI
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000371115800024
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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