Publication
Title
Investigation of the genotoxicity of substances migrating from polycarbonate replacement baby bottles to identify chemicals of high concern
Author
Abstract
Due to the worldwide concern that bisphenol A might act as an endocrine disruptor, alternative materials for polycarbonate (PC) have been introduced on the European market. However, PC -replacement products might also release substances of which the toxicological profile including their genotoxic effects has not yet been. characterized. Because a thorough characterization of the genotoxic profile of all these substances is impossible in the short term, a strategy was developed in order to prioritize those substances for which additional data are urgently needed. The strategy consisted of a decision tree using hazard information related to genotoxicity. The relevant information was obtained from the database of the European Chemicals Agency (ECHA), in silico prediction tools (ToxTree and Derek NexusTM) and the in vitro Vitotox test for detecting DNA damage. By applying the decision tree, substances could be classified into different groups, each characterized by a different probability to induce genotoxic effects. Although none of the investigated substances could be unequivocally identified as genotoxic, the presence of genotoxic effects could neither be excluded for any of them. Consequently, all substances require more data to investigate the genotoxic potential. However, the type and the urge for these data differs among the substances. (C) 2016 Elsevier Ltd. All rights reserved.
Language
English
Source (journal)
Food and chemical toxicology. - Oxford
Publication
Oxford : 2016
ISSN
0278-6915
Volume/pages
89(2016), p. 126-137
ISI
000371556200016
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.04.2016
Last edited 16.09.2017
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