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Title
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Fast and reliable quantitative peptidomics with labelpepmatch
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Author
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Abstract
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| The use of stable isotope tags in quantitative peptidomics offers many advantages, but the laborious identification of matching sets of labeled peptide peaks is still a major bottleneck. Here we present labelpepmatch, an R package for fast and straightforward analysis of LC MS spectra of labeled peptides. This open-source tool offers fast and accurate identification of peak pairs alongside an appropriate framework for statistical inference on quantitative peptidomics data, based on techniques from other-omics disciplines. A relevant case study on the desert locust Schistocerca gregaria proves our pipeline to be a reliable tool for quick but thorough explorative analyses. |
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Language
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English
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Source (journal)
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Journal of proteome research. - -
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Publication
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2016
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ISSN
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1535-3893
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DOI
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10.1021/ACS.JPROTEOME.5B00845
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Volume/pages
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15
:3
(2016)
, p. 1080-1089
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ISI
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000371754100040
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Pubmed ID
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26828777
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Full text (Publisher's DOI)
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Full text (open access)
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