Publication
Title
Human exposure to endocrine, disrupting chemicals and fertility : a case-control study in male subfertility patients
Author
Abstract
Background: Dioxins, PCBs, chlorinated pesticides, brominated flame retardants, bisphenol A, triclosan, perfluorinated compounds and phthalates are known as endocrine disrupting chemicals (EDCs). Objectives: The aim of our study was to investigate whether higher exposure to EDCs is associated with increased subfertility in men. Methods: We measured biomarkers of exposure in 163 men, recruited through four fertility clinics. According to WHO guidelines, we used a total motility count (TMC) of 20 million as cut-off value. We assigned patients to the case group when two semen samples collected at least one week apart had a TMC < 20 and to the control group when both samples had a TMC >= 20. To estimate the risk of subfertility and alteration-in sex hormone concentrations we used multivariable-adjusted analysis, using logistic and linear regressions, respectively. Results: For an IQR increase in serum oxychlordane, the odds ratio for subfertility was 1.98 (95% CI: 1.07; 3.69). Furthermore, men with serum levels of BDE209 above the quantification limit had an odds of 7.22 (1.03; 50.6) for subfertility compared with those having values below the LOQ. Urinary levels of phthalates and triclosan were negatively associated with inhibin B and positively with LH. Urinary bisphenol A correlated negatively with testosterone levels. Conclusions: Our study in men showed that internal body concentrations of endocrine disrupting chemicals are associated with an increased risk of subfertility together with alterations in hormone levels. The results emphasize the importance to reduce chemicals in the environment in order to safeguard male fertility. (C) 2015 Elsevier Ltd. All rights reserved.
Language
English
Source (journal)
Environment international. - Oxford
Publication
Oxford : 2015
ISSN
0160-4120
Volume/pages
84(2015), p. 154-160
ISI
000362143600016
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.04.2016
Last edited 03.08.2017
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