Title
Detailed classification of swimming paths in the Morris Water Maze : multiple strategies within one trialDetailed classification of swimming paths in the Morris Water Maze : multiple strategies within one trial
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Theoretical neurobiology
Publication type
article
Publication
London :Nature Publishing Group,
Subject
Engineering sciences. Technology
Source (journal)
Scientific reports. - London, 2011, currens
Volume/pages
5(2015), 15 p.
ISSN
2045-2322
2045-2322
Article Reference
14562
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representing different animal strategies. However, these approaches typically consider trajectories as a whole, and as a consequence they assign one full trajectory to one class, whereas animals often switch between these strategies, and their corresponding classes, within a single trial. To this end, we take a different approach: we look for segments of diverse animal behaviour within one trial and employ a semi-automated classification method for identifying the various strategies exhibited by the animals within a trial. Our method allows us to reveal significant and systematic differences in the exploration strategies of two animal groups (stressed, non-stressed), that would be unobserved by earlier methods.
E-info
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362081500001&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362081500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Full text (open access)
https://repository.uantwerpen.be/docman/irua/d42ae9/132465.pdf
Handle