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Title
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Barnidipine real-life tolerability in arterial hypertension : results from the BASIC-HT study
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Author
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Abstract
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| Introduction: Blood pressure (BP) is generally poorly controlled in hypertensive patients. One cause is poor adherence to drugs, which can be improved by treatments combining good efficacy and tolerability. Barnidipine is a strong lipophilic calcium channel blocker (CCB) with efficacy similar to other dihydropyridines. Objective: BASIC HT is an observational study in a large population of patients with essential hypertension to evaluate the tolerability of barnidipine in a real-life setting. Methods: 20479 patients were enrolled in the study. Tolerability and efficacy was assessed at 2 visits during a 3-month period. 20275 patients were included in the analysis. Results: Adverse events were reported by 10.6% of the patients, leading to treatment discontinuation in 3%. Events were those expected with CCBs. The drop-out rate was 8%. Mean systolic and diastolic pressure decreased from 159.6 to 138.2 and from 92.5 to 81.7 mmHg. Conclusion: The decrease in BP, is probably due to stimulation of good adherence by barnidipine. |
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Language
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English
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Source (journal)
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Acta clinica Belgica / Belgian Society of Internal Medicine [Ghent]; Royal Belgian Society of Laboratory Medicine. - Gent, 1997, currens
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Publication
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Gent
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2015
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ISSN
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1784-3286
[print]
2295-3337
[online]
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DOI
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10.1179/2295333715Y.0000000012
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Volume/pages
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70
:4
(2015)
, p. 244-250
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ISI
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000359981200002
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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