Title
Occurrence of perchlorate in indoor dust from the United States and eleven other countries : implications for human exposure Occurrence of perchlorate in indoor dust from the United States and eleven other countries : implications for human exposure
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Oxford ,
Subject
Chemistry
Biology
Source (journal)
Environment international. - Oxford
Volume/pages
75(2015) , p. 166-171
ISSN
0160-4120
ISI
000348746600017
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Perchlorate is a widespread environmental contaminant and potent thyroid hormone disrupting compound. Despite this, very little is known with regard to the occurrence of this compound in indoor dust and the exposure of humans to perchlorate through dust ingestion. In this study, 366 indoor dust samples were collected from 12 countries, the USA, Colombia, Greece, Romania, Japan, Korea, Pakistan, Kuwait, Saudi Arabia, India, Vietnam, and China, during 2010-2014. Dust samples were extracted by 1% (v/v) methylamine in water. Analyte separation was achieved by an ion exchange (AS-21) column and analysis was performed by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The overall concentrations of perchlorate in dust were in the range of 0.02-104 mu g/g (geometric mean: 0.41 mu g/g). The indoor dust samples from China contained the highest concentrations (geometric mean: 5.38 mu g/g). No remarkable differences in perchlorate concentrations in dust were found among various microenvironments (i.e., car, home, office, and laboratory). The estimated median daily intake (EDI) of perchlorate for toddlers through dust ingestion in the USA, Colombia, Greece, Romania, Japan, Korea, Pakistan, Kuwait, Saudi Arabia, India, Vietnam, and China was 1.89, 0.37, 1.71, 0.74, 4.90, 720, 0.60, 0.80, 1.55, 0.70, 2.15, and 21.3 ng/kg body weight (bw)/day, respectively. Although high concentrations of perchlorate were measured in some dust samples, the contribution of dust to total perchlorate intake was <5% of the total perchlorate intake in humans. This is the first multinational survey on the occurrence of perchlorate in indoor dust. (C) 2014 Elsevier Ltd. All rights reserved.
E-info
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https://repository.uantwerpen.be/docman/iruaauth/3be96d/132552.pdf
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