Title
Unraveling the triterpenoid saponin biosynthesis of the African shrub **Maesa lanceolata**Unraveling the triterpenoid saponin biosynthesis of the African shrub **Maesa lanceolata**
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Research group
Natural Products and Food - Research and Analysis (NatuRA)
Publication type
article
Publication
Subject
Chemistry
Biology
Source (journal)
Molecular plant
Volume/pages
8(2015):1, p. 122-135
ISSN
1674-2052
ISI
000350812900012
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Maesasaponins produced by the African shrub Maesa lanceolata are oleanane-type saponins with diverse biological activities. Through a combination of transcript profiling of methyl jasmonate-elicited M. lanceolata shoot cultures, functional analysis in transgenic M. lanceolata plants and the heterologous hosts Medicago truncatula and Saccharomyces cerevisiae, we identified three maesaponin biosynthesis genes. These include a beta-amyrin synthase and two cytochrome P450s, CYP716A75 and CYP87D16, which catalyze the C-28 and C-16 alpha oxidations of b-amyrin, respectively.
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https://repository.uantwerpen.be/docman/iruaauth/043b02/132562.pdf
Handle