Publication
Title
Are capillary DBS applicable for therapeutic drug monitoring of common antipsychotics? A proof of concept
Author
Abstract
Aim: DBS sampling has been proposed as an alternative for venous blood collection in therapeutic drug monitoring (TDM) of antipsychotics. For implementation in routine practice, a comparison between capillary and venous blood concentrations is mandatory. Results: A DBS method for quantification of antipsychotics was clinically validated. First, whole blood therapeutic ranges were calculated using the blood:serum ratio. Calculation of DBS:blood ratios and Passing-Bablok regression analysis demonstrated that concentrations obtained by DBS analysis were highly comparable to those obtained by conventional whole blood analysis. Clinical interpretation of serum, whole blood and DBS concentrations were highly identical (sensitivity 91.6-97.6%). Conclusion: This is the first clinical study demonstrating the value of DBS sampling in TDM of antipsychotics.
Language
English
Source (journal)
Bioanalysis
Publication
2015
ISSN
17576180
Volume/pages
7:16(2015), p. 2119-2130
ISI
000360713600016
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.04.2016
Last edited 24.07.2017
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