Title
Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormonerelated peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factorExtracellular matrix protein 1, a direct targeting molecule of parathyroid hormonerelated peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Bethesda, Md,
Subject
Biology
Human medicine
Source (journal)
The FASEB journal / Federation of American Societies for Experimental Biology. - Bethesda, Md
Volume/pages
(2016), p. 1-14
ISSN
0892-6638
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Chondrogenesis and endochondral ossification are precisely controlled by cellular interactions with surrounding matrix proteins and growth factors that mediate cellular signaling pathways. Here, we report that extracellular matrix protein 1 (ECM1) is a previously unrecognized regulator of chondrogenesis. ECM1 is induced in the course of chondrogenesis and its expression in chondrocytes strictly depends on parathyroid hormonerelated peptide (PTHrP) signaling pathway. Overexpression of ECM1 suppresses, whereas suppression of ECM1 enhances, chondrocyte differentiation and hypertrophy in vitro and ex vivo. In addition, target transgene of ECM1 in chondrocytes or osteoblasts in mice leads to striking defects in cartilage development and endochondral bone formation. Of importance, ECM1 seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 rescues disorganized growth plates of PTHrP-null mice. Furthermore, ECM1 and progranulin chondrogenic growth factor constitute an interaction network and act in concert in the regulation of chondrogenesis.Kong, L., Zhao, Y.-P., Tian, Q.-Y., Feng, J.-Q., Kobayashi, T., Merregaert, J., Liu, C.-J. Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormonerelated peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor.
E-info
https://repository.uantwerpen.be/docman/iruaauth/efe867/132803.pdf
Handle