Publication
Title
Designing biomedical proteomics experiments : state-of-the-art and future perspectives
Author
Abstract
With the current expanded technical capabilities to perform mass spectrometry-based biomedical proteomics experiments, an improved focus on the design of experiments is crucial. As it is clear that ignoring the importance of a good design leads to an unprecedented rate of false discoveries which would poison our results, more and more tools are developed to help researchers designing proteomic experiments. In this review, we apply statistical thinking to go through the entire proteomics workflow for biomarker discovery and validation and relate the considerations that should be made at the level of hypothesis building, technology selection, experimental design and the optimization of the experimental parameters.
Language
English
Source (journal)
Expert review of proteomics
Publication
Abingdon : Taylor & francis ltd, 2016
ISSN
1478-9450
1744-8387
Volume/pages
13:5(2016), p. 495-511
ISI
000375848400006
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 09.05.2016
Last edited 09.06.2017
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