Title
Designing biomedical proteomics experiments : state-of-the-art and future perspectives Designing biomedical proteomics experiments : state-of-the-art and future perspectives
Author
Faculty/Department
Faculty of Sciences. Biology
Faculty of Sciences. Chemistry
Faculty of Sciences. Mathematics and Computer Science
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Abingdon :Taylor & francis ltd ,
Subject
Chemistry
Biology
Human medicine
Computer. Automation
Source (journal)
Expert review of proteomics
Volume/pages
13(2016) :5 , p. 495-511
ISSN
1478-9450
ISI
000375848400006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
With the current expanded technical capabilities to perform mass spectrometry-based biomedical proteomics experiments, an improved focus on the design of experiments is crucial. As it is clear that ignoring the importance of a good design leads to an unprecedented rate of false discoveries which would poison our results, more and more tools are developed to help researchers designing proteomic experiments. In this review, we apply statistical thinking to go through the entire proteomics workflow for biomarker discovery and validation and relate the considerations that should be made at the level of hypothesis building, technology selection, experimental design and the optimization of the experimental parameters.
E-info
https://repository.uantwerpen.be/docman/iruaauth/231cfe/133085.pdf
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