Title
Immunological evasion of immediate-early varicella zoster virus proteins
Author
Faculty/Department
Faculty of Sciences. Biology
Faculty of Sciences. Chemistry
Faculty of Sciences. Mathematics and Computer Science
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Berlin ,
Subject
Biology
Human medicine
Computer. Automation
Source (journal)
Immunogenetics. - Berlin
Volume/pages
(2016) , p. 1-4
ISSN
0093-7711
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The varicella zoster virus (VZV) causes the childhood disease commonly known as chickenpox and can later in life reactivate as herpes zoster. The adaptive immune system is known to play an important role in suppressing VZV reactivation. A central aspect of this system is the presentation of VZV-derived peptides by the major histocompatibility complex (MHC) proteins. Here, we investigate if key VZV proteins have evolved their amino acid sequence to avoid presentation by MHC based on predictive models of MHC-peptide affinity. This study shows that the immediate-early proteins of all characterized VZV strains are profoundly depleted for high-affinity MHC-I-restricted epitopes. The same depletion can be found in its closest animal analog, the simian varicella virus. Further orthology analysis towards other herpes viruses suggests that the protein amino acid frequency is one of the primary drivers of targeted epitope depletion.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/db11fe/133096.pdf
E-info
https://repository.uantwerpen.be/docman/iruaauth/fde5b1/133096.pdf
Handle