Publication
Title
Anesthesia effect on single local field potentials variability in rat barrel cortex : preliminary results
Author
Abstract
The rat barrel cortex is a widely used model of information processing in the somatosensory area, thanks to its precise and easily recognizable organization. However, evoked Local Field Potentials (LFPs) generated in the barrel cortex by repetitive deflections of rat whiskers show large variability in shapes and timings. Moreover, anesthetics can deeply affect the profile of evoked responses. This paper presents preliminary report on the variability and the effect of commonly used anesthetics on these signals. We studied representative signal shape characteristics (e.g., latency and amplitude of events) extracted from evoked responses acquired by means of standard Ag/AgCl electrodes from different cortical layers. As an early result, we found significant difference in the latency of the first principal peak of the responses. Under Tiletamine-Xylazine anesthetic, the responses or events of the evoked LFPs occurred later than the ones recorded while urethane was administered. Furthermore, the distributions of the peak latencies in all cortical layers were narrower in case of Urethane. This behavior should be attributed to the different effects of these two anesthetics on specific synaptic receptors and thus on the processing of neural information and the encoding of sensory input along the cortical pathway.
Language
English
Source (journal)
IEEE Engineering in medicine and biology society conference proceedings
MEDICINE AND BIOLOGY SOCIETY (EMBC)
Source (book)
37th Annual International Conference of the IEEE Engineering in Medicine, and Biology Society (EMBC), AUG 25-29, 2015, Milan, ITALY
Publication
New york : Ieee, 2015
ISBN
978-1-4244-9270-1
Volume/pages
(2015), p. 4721-4724
ISI
000371717205001
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 10.05.2016
Last edited 11.11.2017
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