Title
Anesthesia effect on single local field potentials variability in rat barrel cortex : preliminary results Anesthesia effect on single local field potentials variability in rat barrel cortex : preliminary results
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
conferenceObject
Publication
New york :Ieee ,
Source (journal)
MEDICINE AND BIOLOGY SOCIETY (EMBC)
IEEE Engineering in medicine and biology society conference proceedings
Source (book)
37th Annual International Conference of the IEEE Engineering in Medicine, and Biology Society (EMBC), AUG 25-29, 2015, Milan, ITALY
Volume/pages
(2015) , p. 4721-4724
ISSN
1557-170X
ISBN
978-1-4244-9270-1
ISI
000371717205001
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
The rat barrel cortex is a widely used model of information processing in the somatosensory area, thanks to its precise and easily recognizable organization. However, evoked Local Field Potentials (LFPs) generated in the barrel cortex by repetitive deflections of rat whiskers show large variability in shapes and timings. Moreover, anesthetics can deeply affect the profile of evoked responses. This paper presents preliminary report on the variability and the effect of commonly used anesthetics on these signals. We studied representative signal shape characteristics (e.g., latency and amplitude of events) extracted from evoked responses acquired by means of standard Ag/AgCl electrodes from different cortical layers. As an early result, we found significant difference in the latency of the first principal peak of the responses. Under Tiletamine-Xylazine anesthetic, the responses or events of the evoked LFPs occurred later than the ones recorded while urethane was administered. Furthermore, the distributions of the peak latencies in all cortical layers were narrower in case of Urethane. This behavior should be attributed to the different effects of these two anesthetics on specific synaptic receptors and thus on the processing of neural information and the encoding of sensory input along the cortical pathway.
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