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Title
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Interleukin-25 is detrimental for recovery after spinal cord injury in mice
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Author
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Abstract
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| Background: The cytokine, interleukin (IL)-25, is thought to be critically involved in inducing a type 2 immune response which may contribute to regeneration after central nervous system (CNS) trauma. We investigated whether applying recombinant IL-25, locally or systemically, in a mouse model of spinal cord injury (SCI) improves functional and histological recovery. Findings: Repeated systemic administration of IL-25 did not influence functional recovery following SCI. In contrast, a single local administration of IL-25 significantly worsened locomotor outcome, which was evident from a decreased Basso mouse scale (BMS) score compared with phosphate-buffered saline (PBS)-treated controls. This was accompanied by a significant increase in lesion size, demyelination, and T helper cell infiltration. Conclusions: These data show for the first time that IL-25 is either ineffective when applied systemically or detrimental to spinal cord recovery when applied locally. Our findings question the potential neuroprotective role of IL-25 following CNS trauma. |
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Language
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English
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Source (journal)
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Journal of neuroinflammation. - London
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Publication
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London
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2016
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ISSN
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1742-2094
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DOI
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10.1186/S12974-016-0566-Y
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Volume/pages
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13
(2016)
, 6 p.
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Article Reference
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101
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ISI
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000375900000001
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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