Title
Oxidative stress ecology and the d-ROMs test : facts, misfacts and an appraisal of a decade's work Oxidative stress ecology and the d-ROMs test : facts, misfacts and an appraisal of a decade's work
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Berlin ,
Subject
Psychology
Chemistry
Biology
Source (journal)
Behavioral ecology and sociobiology. - Berlin
Volume/pages
70(2016) :5 , p. 809-820
ISSN
0340-5443
ISI
000374563600016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In recent years, behavioural ecologists have taken to studying oxidative stress in free-ranging organisms because it has been proposed as an important mediator of life-history trade-offs. A plethora of methodological approaches to quantify biomarkers associated with oxidative stress exist, each one with its own strengths and weaknesses. The d-ROMs test has emerged as one of the favoured assays in ecological studies because of its reliability, sensitivity to specific perturbations of the organism's oxidative balance and medical and ecological relevance. Criticisms have been, however, raised about its specificity for oxidative damage. In this article, I have reviewed basic information about the d-ROMs test, its validation, the methodological mistakes made in the studies that attempted to criticise this assay and the application of this assay to ecological studies of oxidative stress. All the direct and indirect evidences show that the d-ROMs test is a valuable assay for the quantification of plasma or serum primary (or early) oxidative damage molecules and, possibly, of other biological matrices and provides ecologically relevant information.
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