Publication
Title
Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition
Author
Abstract
Introduction In Alzheimer's disease (AD), pathologic amyloid-beta (Aβ) is synaptotoxic and impairs neuronal function at the microscale, influencing brain networks at the macroscale before Aβ deposition. The latter can be detected noninvasively, in vivo, using resting-state functional MRI (rsfMRI), a technique used to assess brain functional connectivity (FC). Methods RsfMRI was performed longitudinally in TG2576 and PDAPP mice, starting before Aβ deposition to determine the earliest FC changes. Additionally, the role of pathologic Aβ on early FC alterations was investigated by treating TG2576 mice with the 3D6 anti-Aβ-antibody. Results Both transgenic models showed hypersynchronized FC before Aβ deposition and hyposynchronized FC at later stages. Early anti-Aβ treatment in TG2576 mice prevented hypersynchronous FC and the associated synaptic impairments and excitatory/inhibitory disbalances. Discussion Hypersynchrony of FC may be used as a new noninvasive read out of early AD and can be recovered by anti-Aβ treatment, encouraging preventive treatment strategies in familial AD.
Language
English
Source (journal)
Alzheimer's & dementia. - Place of publication unknown
Publication
Place of publication unknown : 2016
ISSN
1552-5260
Volume/pages
12:9(2016), p. 964-976
ISI
000383215500004
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
[E?say:metaLocaldata.cgzprojectinf]
Imaging of Neuroinflammation in Neurodegenerative Diseases (INMIND).
Preclinical development of an innovative immune therapy based on CD56 + dendritic cells and interleukin-15: recruitment of the innate immune system in the fight against cancer.
Molecular Imaging of Brain Pathophysiology (BrainPath).
Clarity in the clouded brain, establishing spatiotemporal fingerprints of neurodegeneration using whole brain imaging.
Sleep deprivation, soluble Amyloid ɴand the glymphatic system. A neurotoxic triad during Alzheimer's Disease?
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 06.06.2016
Last edited 14.08.2017
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