Publication
Title
Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against **Staphylococcus aureus**
Author
Abstract
The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel antibiotics. In the present study, we synthesized 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator. These efforts resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans, and in a mouse mammary gland infection model, without showing cytotoxicity.
Language
English
Source (journal)
Angewandte Chemie: international edition in English. - Weinheim
Publication
Weinheim : 2016
ISSN
1433-7851
0570-0833
Volume/pages
55:22(2016), p. 6551-6555
ISI
000377921200035
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 07.06.2016
Last edited 03.12.2017
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