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Title
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Direct compression properties of melt-extruded isomalt
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Author
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Abstract
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| Isomalt, a sugar alcohol, was melt-extruded prior to compression in order to improve its tabletting properties. After fusion, crystalline isomalt was transformed into an amorphous form as shown by X-ray diffraction and differential scanning calorimetry (DSC). The tabletting properties of amorphous isomalt were dramatically improved. Mixtures formulated with paracetamol (50%) and extruded isomalt yielded hard tablets. However, extruded isomalt powder showed agglomeration problems due to recrystallization of the amorphous phase into a stable crystalline form in the presence of atmospheric moisture. The evolution of the moisture content correlated well with the compressibility data. The tablets made of extruded isomalt powder had a lower friability in comparison to the tablets formulated with non-extruded isomalt powder. Their disintegration was fast and a rapid dissolution rate was recorded. Extruded isomalt displayed excellent tabletting properties; however, further experiments should be conducted to delay or even prevent recrystallization of amorphous isomalt. |
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Language
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English
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Source (journal)
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International journal of pharmaceutics. - Amsterdam
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Publication
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Amsterdam
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2002
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ISSN
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0378-5173
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DOI
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10.1016/S0378-5173(01)00993-0
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Volume/pages
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235
(2002)
, p. 149-157
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ISI
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000174725200016
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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