Effect of the substrate-binder interactions on the mechanical properties ofcompactsEffect of the substrate-binder interactions on the mechanical properties ofcompacts
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Acta pharmaceutica Hungarica. - Budapest
68(1998):6, p. 332-335
The effect of the substrate-binder interfacial interaction in granules,made of PVP and glass ballotini as model substrates, on the mechanical properties of rectangular compactsconsisting of these granules was investigated by use of the four-point beam bending technique. The mechanicalproperties of the prepared compacts were correlated with the physico-chemical characteristics--contactangle, surface tension and binder concentration--of the granulation liquid. The mechanical strength andYoung's modulus of the specimens both reached a maximum value when the binder concentration in the granulationliquid was increased to 20% (w/v) for all granulation liquid volumes used. Above a 20% PVP concentration,the increasing granulation liquid contact angle hindered the binder spreading, creating weak regionsin the compact and decreasing its mechanical strength.