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Title
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Effect of the substrate-binder interactions on the mechanical properties ofcompacts
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Author
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Abstract
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| The effect of the substrate-binder interfacial interaction in granules,made of PVP and glass ballotini as model substrates, on the mechanical properties of rectangular compactsconsisting of these granules was investigated by use of the four-point beam bending technique. The mechanicalproperties of the prepared compacts were correlated with the physico-chemical characteristics--contactangle, surface tension and binder concentration--of the granulation liquid. The mechanical strength andYoung's modulus of the specimens both reached a maximum value when the binder concentration in the granulationliquid was increased to 20% (w/v) for all granulation liquid volumes used. Above a 20% PVP concentration,the increasing granulation liquid contact angle hindered the binder spreading, creating weak regionsin the compact and decreasing its mechanical strength. |
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Language
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English
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Source (journal)
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Acta pharmaceutica Hungarica. - Budapest
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Publication
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Budapest
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1998
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ISSN
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0001-6659
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Volume/pages
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68
:6
(1998)
, p. 332-335
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