Publication
Title
Effect of the substrate-binder interactions on the mechanical properties ofcompacts
Author
Abstract
The effect of the substrate-binder interfacial interaction in granules,made of PVP and glass ballotini as model substrates, on the mechanical properties of rectangular compactsconsisting of these granules was investigated by use of the four-point beam bending technique. The mechanicalproperties of the prepared compacts were correlated with the physico-chemical characteristics--contactangle, surface tension and binder concentration--of the granulation liquid. The mechanical strength andYoung's modulus of the specimens both reached a maximum value when the binder concentration in the granulationliquid was increased to 20% (w/v) for all granulation liquid volumes used. Above a 20% PVP concentration,the increasing granulation liquid contact angle hindered the binder spreading, creating weak regionsin the compact and decreasing its mechanical strength.
Language
English
Source (journal)
Acta pharmaceutica Hungarica. - Budapest
Publication
Budapest : 1998
ISSN
0001-6659
Volume/pages
68:6(1998), p. 332-335
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Record
Identification
Creation 09.06.2016
Last edited 16.06.2016