Title
|
|
|
|
Wax beads as cushioning agents during the compression of coated diltiazem pellets
|
|
Author
|
|
|
|
|
|
Abstract
|
|
|
|
Placebo particles were mixed with film-coated diltiazem pellets to evaluate them as cushioning agents during tabletting in order to protect the film coat from damage. The cushioning properties of α-lactose monohydrate granules, microcrystalline cellulose pellets and wax/starch beads were evaluated by comparing the dissolution profile of the coated pellets before and after compression (compression force 10 kN). Only the tablet formulations containing wax/starch beads provided protection to the film coat. However, the dissolution rate of tablets formulated with waxy maltodextrin/paraffinic wax placebo beads was too slow as the tablets did not disintegrate. Adding 50% (w/w) drum-dried corn starch/Explotab®/paraffinic wax beads to the formulation was the optimal amount of cushioning beads to provide sufficient protection for the film coat and yield disintegrating tablets. Using a compression simulator, the effect of precompression force and compression time on the dissolution rate was found to be insignificant. The diametral crushing strength of tablets containing 50% (w/w) drum-dried corn starch/Explotab®/paraffinic wax beads was about 25.0 N (±0.3 N), with a friability of 0.4% (±0.04%). This study demonstrates that adding deformable wax pellets minimizes the damage to film-coated pellets during compression. |
|
|
Language
|
|
|
|
English
|
|
Source (journal)
|
|
|
|
European journal of pharmaceutical sciences. - Amsterdam, 1993, currens
|
|
Publication
|
|
|
|
Amsterdam
:
2002
|
|
ISSN
|
|
|
|
0928-0987
|
|
DOI
|
|
|
|
10.1016/S0928-0987(02)00164-1
|
|
Volume/pages
|
|
|
|
17
:3
(2002)
, p. 145-151
|
|
ISI
|
|
|
|
000179131500004
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|