Title
Wax beads as cushioning agents during the compression of coated diltiazem pellets Wax beads as cushioning agents during the compression of coated diltiazem pellets
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Amsterdam ,
Subject
Pharmacology. Therapy
Source (journal)
European journal of pharmaceutical sciences. - Amsterdam, 1993, currens
Volume/pages
17(2002) :3 , p. 145-151
ISSN
0928-0987
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Placebo particles were mixed with film-coated diltiazem pellets to evaluate them as cushioning agents during tabletting in order to protect the film coat from damage. The cushioning properties of α-lactose monohydrate granules, microcrystalline cellulose pellets and wax/starch beads were evaluated by comparing the dissolution profile of the coated pellets before and after compression (compression force 10 kN). Only the tablet formulations containing wax/starch beads provided protection to the film coat. However, the dissolution rate of tablets formulated with waxy maltodextrin/paraffinic wax placebo beads was too slow as the tablets did not disintegrate. Adding 50% (w/w) drum-dried corn starch/Explotab®/paraffinic wax beads to the formulation was the optimal amount of cushioning beads to provide sufficient protection for the film coat and yield disintegrating tablets. Using a compression simulator, the effect of precompression force and compression time on the dissolution rate was found to be insignificant. The diametral crushing strength of tablets containing 50% (w/w) drum-dried corn starch/Explotab®/paraffinic wax beads was about 25.0 N (±0.3 N), with a friability of 0.4% (±0.04%). This study demonstrates that adding deformable wax pellets minimizes the damage to film-coated pellets during compression.
E-info
https://repository.uantwerpen.be/docman/iruaauth/44e64c/133813.pdf