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Title
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Stereoselective monoamine oxidase-catalyzed oxidative aza-Friedel-Crafts reactions of meso-pyrrolidines in aqueous buffer
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Author
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Abstract
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| We disclose the highly diastereoselective combination of monoamine oxidase-catalyzed oxidation of meso-pyrrolidines and aza-FriedelCrafts reactions in aqueous buffer to give valuable enantioenriched 2-substituted pyrrolidines in a formal double C[BOND]H activation process. A range of secondary as well as tertiary amines were shown to be suitable substrates for the biocatalytic oxidation and subsequent addition of a variety of C-nucleophiles. |
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Language
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English
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Source (journal)
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Advanced synthesis and catalysis. - Weinheim, 2001, currens
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Publication
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Weinheim
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2016
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ISSN
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1615-4150
[print]
1615-4169
[online]
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DOI
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10.1002/ADSC.201600038
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Volume/pages
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358
:10
(2016)
, p. 1555-1560
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ISI
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000377268100002
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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