Publication
Title
Stereoselective monoamine oxidase-catalyzed oxidative aza-Friedel-Crafts reactions of meso-pyrrolidines in aqueous buffer
Author
Abstract
We disclose the highly diastereoselective combination of monoamine oxidase-catalyzed oxidation of meso-pyrrolidines and aza-FriedelCrafts reactions in aqueous buffer to give valuable enantioenriched 2-substituted pyrrolidines in a formal double C[BOND]H activation process. A range of secondary as well as tertiary amines were shown to be suitable substrates for the biocatalytic oxidation and subsequent addition of a variety of C-nucleophiles.
Language
English
Source (journal)
Advanced synthesis and catalysis. - Weinheim
Publication
Weinheim : 2016
ISSN
1615-4150
Volume/pages
358:10(2016), p. 1555-1560
ISI
000377268100002
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 15.06.2016
Last edited 08.06.2017
To cite this reference