Effects of the lyophilized aqueous extract form the root bark of **Perianthus Longifolia miers** (menispermaceae) on sexual behaviors of normal male wistar rats and its acute toxicity
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
Pharmacology. Therapy
Source (journal)
World journal of pharmacy and pharmaceutical sciences
5(2016) :4 , p. 135-155
Target language
English (eng)
Full text (Publishers DOI)
University of Antwerp
The present study revealed the effects of the lyophilized aqueous extract from Perianthus longifolia or P. longifolius root bark on some sexual behavior in male Wistar rats. The overall results showed that the extract possesses aphrodisiac properties by the oral administration of the lyophilized aqueous extract at respective doses of 100, 200 and 400 mg/kg body weight in term of significant increase in dose-dependent manner of mount frequency, intromission frequency, ejaculation frequency, copulatory efficiency, number of intromission and penile trusting, spontaneous penile erection, number of spermatozoa and its mobility, and serum testosterone. On the other hand, it was also observed that the oral administration of the same oral doses induced in dose-dependent manner significant decrease of other sexual parameters behavior such as mount frequency, intromission latency, ejaculation latency, mount latency and inter-intromission interval which are also claimed as evidences for aphrodisiac property. The extract also showed good increase in potency parameters such as erection, quick flip, long fi-lip and total reflex. All these effects of the lyophilized aqueous extract of P. longifolia root bark on evaluated sexual behavior more confirm its aphrodiac properties The oral dose of 200 mg/kg was found to be more effective than other administered oral doses. In acute toxicity, the extract was found non-toxic since no death or other changes in behaviour of treated animals was observed, Its LD50 was estimated to be greater than 5 g/kg body weight. The results more support and justify the use of this plant part to treat erection dysfunction and to enhance sexual behavior of men in traditional medicine as a natural aphrodiac agent.