Publication
Title
Anti-infective, cytotoxic and antioxidant activity of Ziziphus oxyphylla and Cedrela serrata
Author
Abstract
Objective To search for the most active antimicrobial and antioxidant sub-fractions related to traditional use of Ziziphus oxyphylla (Z. oxyphylla) and Cedrela serrata (C. serrata) in Pakistan against infectious and liver diseases. Methods Factions of different polarity were tested in vitro for their antiprotozoal, antimalarial, antibacterial and antifungal activity against different pathogens. Cytotoxicity on MRC-5 cell lines (human lung fibroblasts) as well as, in vitro radical scavenging activity was evaluated using the 1, 1-diphenyl-2-picrylhydrazyl radical assay. Results The highest antiprotozoal activity was observed for the CHCl3 fractions of Z. oxyphylla roots and leaves, and C. serrata bark. The CHCl3 and EtOAc fractions of Z. oxyphylla roots, the CHCl3 fraction of Z. oxyphylla leaves, the EtOAc and the residual MeOH: H2O fraction of C. serrata bark showed antibacterial activity against Staphylococcus aureus. The same residual MeOH: H2O fraction of C. serrata bark was active against Candida albicans. The highest antioxidant activity was observed for the more hydrophilic EtOAc fractions of Z. oxyphylla leaves, C. serrata bark and leaves, and the residual MeOH: H2O fraction of C. serrata bark. Conclusions This study supports at least in part the traditional uses of these plants for antimicrobial purposes and against liver diseases.
Language
English
Source (journal)
Asian Pacific journal of tropical biomedicine. - -
Publication
2016
ISSN
2221-1691
Volume/pages
6:8(2016), p. 671-676
Full text (Publishers DOI)
Full text (open access)
UAntwerpen
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Research group
Publication type
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Affiliation
Publications with a UAntwerp address
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Creation 07.07.2016
Last edited 22.11.2016
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