Publication
Title
Immune evasion strategies of Trypanosoma brucei within the mammalian host : progression to pathogenicity
Author
Abstract
The diseases caused by African trypanosomes (AT) are of both medical and veterinary importance and have adversely influenced the economic development of sub-Saharan Africa. Moreover, so far not a single field applicable vaccine exists, and chemotherapy is the only strategy available to treat the disease. These strictly extracellular protozoan parasites are confronted with different arms of the hosts immune response (cellular as well as humoral) and via an elaborate and efficient (vector)parasitehost interplay they have evolved efficient immune escape mechanisms to evade/manipulate the entire host immune response. This is of importance, since these parasites need to survive sufficiently long in their mammalian/vector host in order to complete their life cycle/transmission. Here, we will give an overview of the different mechanisms AT (i.e. T. brucei as a model organism) employ, comprising both tsetse fly saliva and parasite-derived components to modulate host innate immune responses thereby sculpturing an environment that allows survival and development within the mammalian host.
Language
English
Source (journal)
Frontiers in immunology. - Place of publication unknown
Publication
Lausanne : Frontiers media sa, 2016
ISSN
1664-3224
Volume/pages
7(2016), 14 p.
Article Reference
233
ISI
000378377800001
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 07.07.2016
Last edited 22.10.2017
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