|
Title
|
|
|
|
Randomized trial of TAS-102 for refractory metastatic colorectal cancer
| |
|
Author
|
|
|
|
| |
|
Institution/Organisation
|
|
|
|
RECOURSE Study Grp
| |
|
Abstract
|
|
|
|
| BACKGROUND Early clinical trials conducted primarily in Japan have shown that TAS-102, an oral agent that combines trifluridine and tipiracil hydrochloride, was effective in the treatment of refractory colorectal cancer. We conducted a phase 3 trial to further assess the efficacy and safety of TAS-102 in a global population of such patients. METHODS In this double-blind study, we randomly assigned 800 patients, in a 2: 1 ratio, to receive TAS-102 or placebo. The primary end point was overall survival. RESULTS The median overall survival improved from 5.3 months with placebo to 7.1 months with TAS-102, and the hazard ratio for death in the TAS-102 group versus the placebo group was 0.68 (95% confidence interval [CI], 0.58 to 0.81; P<0.001). The most frequently observed clinically significant adverse events associated with TAS-102 were neutropenia, which occurred in 38% of those treated, and leukopenia, which occurred in 21%; 4% of the patients who received TAS-102 had febrile neutropenia, and one death related to TAS-102 was reported. The median time to worsening performance status (a change in Eastern Cooperative Oncology Group performance status [on a scale of 0 to 5, with 0 indicating no symptoms and higher numbers indicating increasing degrees of disability] from 0 or 1 to 2 or more) was 5.7 months with TAS-102 versus 4.0 months with placebo (hazard ratio, 0.66; 95% CI, 0.56 to 0.78; P<0.001). CONCLUSIONS In patients with refractory colorectal cancer, TAS-102, as compared with placebo, was associated with a significant improvement in overall survival. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
The New England journal of medicine. - Boston, Mass., 1928, currens
| |
|
Publication
|
|
|
|
Boston, Mass.
:
2015
| |
|
ISSN
|
|
|
|
0028-4793
[print]
1533-4406
[online]
| |
|
DOI
|
|
|
|
10.1056/NEJMOA1414325
| |
|
Volume/pages
|
|
|
|
372
:20
(2015)
, p. 1909-1919
| |
|
ISI
|
|
|
|
000354493300006
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (publisher's version - intranet only)
|
|
|
|
| |
|