Title
Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454 Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Viruses
Volume/pages
7(2015) :1 , p. 239-251
ISSN
1999-4915
ISI
000348401600011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/3ef1a9/134428.pdf
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