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Title
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Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454
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Author
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Abstract
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| Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54. |
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Language
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English
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Source (journal)
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Viruses
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Publication
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2015
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ISSN
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1999-4915
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DOI
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10.3390/V7010239
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Volume/pages
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7
:1
(2015)
, p. 239-251
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ISI
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000348401600011
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Full text (Publisher's DOI)
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Full text (open access)
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