Title
Bioavailability of two licensed paediatric rifampicin suspensions: implications for quality control programmes Bioavailability of two licensed paediatric rifampicin suspensions: implications for quality control programmes
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Paris ,
Subject
Human medicine
Source (journal)
International journal of tuberculosis and lung disease. - Paris
Volume/pages
20(2016) :7 , p. 915-919
ISSN
1027-3719
ISI
000378189200014
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
SETTING: To assess the revised World Health Organization-recommended dose of 10-20 mg/kg rifampicin (RMP), we studied the steady state pharmacokinetics of RMP in South African children who received standard treatment for drug-susceptible tuberculosis (TB). OBJECTIVE: To determine the formulation effect on the pharmacokinetics of RMP. DESIGN: RMP plasma concentrations were characterised in 146 children (median age 1.4 years, range 0.2-10.2). The morning dose on the day of the pharmacokinetic evaluation was administered as one of two RMP single-drug oral suspensions. RESULTS: While one formulation achieved 2 h concentrations in the range of those observed in adults (median 6.54 mg/l, interquartile range [IQR] 4.47-8.84), the other attained a median bioavailability of only 25% of this, with a median 2 h concentration of 1.59 mg/l (IQR 0.89-2.38). CONCLUSION: RMP is a key drug for the treatment of TB. It is critical that the quality of RMP suspensions used to treat childhood TB is ensured.
E-info
https://repository.uantwerpen.be/docman/iruaauth/64307b/134627.pdf
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Handle