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Title
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Group A streptococcal meningitis : emm type distribution and theoretical vaccine coverage in children
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Author
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Abstract
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| As group A Streptococcus (GAS) meningitis is seldom reported in children, emm-type distribution data are scare. We report eight cases of GAS meningitis in Belgium (2008-2013) and compare molecular characteristics of our strains with a further 55 cases previously reported with their corresponding emm-types. emm1 type was the most frequent (24%) followed by emm6 (11%), emm12 (11%) and emm3 (6%). Together these four emm-types accounted for 52% of the cases, while the rest of the cases are due to 24 different emm-types. These 28 emm-types associated with GAS meningitis belonged to 16 different emm-clusters suggesting that there is no propensity for particular emm-types or emm-cluster to cause meningitis. Theoretical coverage of the 30-valent vaccine candidate would be 77.8% (49/63 isolates) among children with GAS meningitis. |
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Language
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English
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Source (journal)
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Acta clinica Belgica / Belgian Society of Internal Medicine [Ghent]; Royal Belgian Society of Laboratory Medicine. - Gent, 1997, currens
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Publication
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Gent
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2016
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ISSN
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1784-3286
[print]
2295-3337
[online]
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DOI
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10.1179/2295333715Y.0000000066
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Volume/pages
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71
:3
(2016)
, p. 138-141
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ISI
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000378349600003
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Pubmed ID
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26319426
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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