Title
Group A streptococcal meningitis : emm type distribution and theoretical vaccine coverage in children Group A streptococcal meningitis : emm type distribution and theoretical vaccine coverage in children
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Gent ,
Subject
Human medicine
Source (journal)
Acta clinica Belgica. - Gent, 1997, currens
Volume/pages
71(2016) :3 , p. 138-141
ISSN
1784-3286
ISI
000378349600003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
As group A Streptococcus (GAS) meningitis is seldom reported in children, emm-type distribution data are scare. We report eight cases of GAS meningitis in Belgium (2008-2013) and compare molecular characteristics of our strains with a further 55 cases previously reported with their corresponding emm-types. emm1 type was the most frequent (24%) followed by emm6 (11%), emm12 (11%) and emm3 (6%). Together these four emm-types accounted for 52% of the cases, while the rest of the cases are due to 24 different emm-types. These 28 emm-types associated with GAS meningitis belonged to 16 different emm-clusters suggesting that there is no propensity for particular emm-types or emm-cluster to cause meningitis. Theoretical coverage of the 30-valent vaccine candidate would be 77.8% (49/63 isolates) among children with GAS meningitis.
E-info
https://repository.uantwerpen.be/docman/iruaauth/979def/134637.pdf
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Handle