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Title
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The spatial arrangement of blastomeres at the 4-cell stage and IVF outcome
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Author
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Abstract
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| This study compared the developmental and implantation potential of tetrahedrally arranged versus non-tetrahedrally arranged 4-cell-stage embryos. If the cleavage planes of a 4-cell-stage embryo were perpendicularly orientated, blastomeres were defined as tetrahedrally arranged, while embryos with parallel-orientated cleavage axes were considered as non-tetrahedral embryos. The 4-cell-stage embryos (n = 862) examined in this study were obtained from 299 patients aged <36 years. A total of 299 embryos were transferred as a single-embryo transfer on day 3. This study showed that tetrahedral embryos developed into a 8-cell-stage embryo on day 3 more frequently (307, 45% versus 42, 24%; P < 0.0001) and also developed more frequently into good-quality embryos (461, 67% versus 67, 38%; P < 0.0001) and into excellent-quality embryos (290, 42% versus 34, 19%; P < 0.0001). Tetrahedral embryos had a significantly higher implantation potential (98, 38% versus 9, 21%; P = 0.038), ongoing pregnancy rate (84, 33% versus 7, 16%; P = 0.032) and live birth rate (84, 33% versus 7, 16%; P = 0.032). In conclusion, tetrahedral 4-cell-stage embryos on day 2 developed into embryos of better quality on day 3 with a higher implantation potential and live birth rate compared with non-tetrahedral 4-cell-stage embryos. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Reproductive biomedicine online. - Cambridge
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Publication
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Cambridge
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2014
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ISSN
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1472-6483
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DOI
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10.1016/J.RBMO.2013.10.008
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Volume/pages
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28
:2
(2014)
, p. 198-203
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ISI
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000330573600009
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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