Publication
Title
Characterization of a top quality embryo, a step towards single-embryo transfer
Author
Abstract
In most in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICST) programmes approximately one ongoing pregnancy in three is multiple, The need to characterize embryos with optimal implantation potential is obvious. We retrospectively examined all of 23 double transfers resulting in ongoing twins, occurring between January 1, 1996 and May 19, 1997, Characteristics of these top quality embryos were absence of multinucleated blastomeres, four or five blastomeres on day 2, seven or more cells on day 3, and less than or equal to 20% anucleated fragments. In a subsequent series of 400 IVF/ICSI cycles (out of which 372 were selected for embryo transfer) from May 20, 1997 to July 31, 1998, only women <38 years of age had multiple pregnancies: after 221 transfers of two embryos, 45/116 (39%) were multiple, and after 77 transfers of >2 embryos, 11/31 (35%) were multiple, We applied our top quality criteria to the 221 double transfers: 106 transfers with two top embryos resulted in 65 (63%) ongoing pregnancies with 37 (57%) twins, 65 transfers with one top embryo in 38 (58%) ongoing pregnancies with eight (21%) twins. Tn the group without top embryos, 12/52 (23%) ongoing singletons occurred, with no twins. The corresponding ongoing implantation rates were 49, 35 and 12%, This analysis suggests that single embryo transfer with an acceptable pregnancy rate might be considered if a top quality embryo is available.
Language
English
Source (journal)
Human reproduction. - Bonn
Publication
Bonn : 1999
ISSN
0268-1161
Volume/pages
14:9(1999), p. 2345-2349
ISI
000082564300034
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 18.08.2016
Last edited 17.09.2017