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Title
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Absolute configuration of the antimalarial erythro-mefloquine Vibrational Circular Dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative
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Author
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Abstract
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| The long-standing discussion of the absolute configuration of erythro-mefloquine is revisited, showcasing the strength of a combination of experimental and calculated Vibrational Circular Dichroism spectroscopy. The resulting assignment of one of the most important antimalarials is subsequently confirmed by Electronic Circular Dichroism spectroscopy and X-ray diffraction-based structure elucidation of thiourea derivates, adding to the amount of evidence on the absolute configuration that had long remained a matter of debate. |
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Language
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English
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Source (journal)
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RSC advances
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Publication
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2016
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ISSN
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2046-2069
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DOI
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10.1039/C6RA19367F
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Volume/pages
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6
:85
(2016)
, p. 81461-81465
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ISI
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000382776000001
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Full text (Publisher's DOI)
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Full text (open access)
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