Title
Absolute configuration of the antimalarial erythro-mefloquine Vibrational Circular Dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative Absolute configuration of the antimalarial erythro-mefloquine Vibrational Circular Dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Subject
Chemistry
Source (journal)
RSC advances
Volume/pages
6(2016) :85 , p. 81461-81465
ISSN
2046-2069
ISI
000382776000001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The long-standing discussion of the absolute configuration of erythro-mefloquine is revisited, showcasing the strength of a combination of experimental and calculated Vibrational Circular Dichroism spectroscopy. The resulting assignment of one of the most important antimalarials is subsequently confirmed by Electronic Circular Dichroism spectroscopy and X-ray diffraction-based structure elucidation of thiourea derivates, adding to the amount of evidence on the absolute configuration that had long remained a matter of debate.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/816f54/11711.pdf
https://repository.uantwerpen.be/docman/irua/0601c8/134836.pdf
Handle