Title
Amine activation : synthesis of N‑(hetero)arylamides from isothioureas and carboxylic acids Amine activation : synthesis of N‑(hetero)arylamides from isothioureas and carboxylic acids
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Washington, D.C. ,
Subject
Chemistry
Source (journal)
Organic letters / American Chemical Society. - Washington, D.C.
Volume/pages
18(2016) :18 , p. 4602-4605
ISSN
1523-7060
ISI
000383640600040
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.
E-info
https://repository.uantwerpen.be/docman/iruaauth/6f4f1a/134837.pdf
Handle