Amine activation : synthesis of N‑(hetero)arylamides from isothioureas and carboxylic acidsAmine activation : synthesis of N‑(hetero)arylamides from isothioureas and carboxylic acids
Faculty of Sciences. Chemistry
Department of Chemistry - other
2016Washington, D.C., 2016
Organic letters / American Chemical Society. - Washington, D.C.
(2016), p. 1-4
University of Antwerp
A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.