Publication
Title
Adiponectin resistance in skeletal muscle : pathophysiological implications in chronic heart failure
Author
Abstract
Skeletal muscle wasting is a common complication of chronic heart failure (CHF) and linked to poor patient prognosis. In recent years, adiponectin was postulated to be centrally involved in CHF-associated metabolic failure and muscle wasting. This review discusses current knowledge on the role of adiponectin in CHF. Particular emphasis will be given to the complex interaction mechanisms and the intracellular pathways underlying adiponectin resistance in skeletal muscle of CHF patients. In this review, we propose that the resistance process is multifactorial, integrating abnormalities emanating from insulin signalling, mitochondrial biogenesis, and ceramide metabolism.
Language
English
Source (journal)
Journal of cachexia, sarcopenia and muscle. - Heidelburg, 2010, currens
Publication
Heidelburg : Springer-Verlag, 2016
ISSN
2190-5991
Volume/pages
7:3(2016), p. 261-274
ISI
000379868200003
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 02.09.2016
Last edited 25.09.2017
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