Title
Adiponectin resistance in skeletal muscle : pathophysiological implications in chronic heart failure Adiponectin resistance in skeletal muscle : pathophysiological implications in chronic heart failure
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Heidelburg :Springer-Verlag ,
Subject
Human medicine
Source (journal)
Journal of cachexia, sarcopenia and muscle. - Heidelburg, 2010, currens
Volume/pages
7(2016) :3 , p. 261-274
ISSN
2190-5991
ISI
000379868200003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Skeletal muscle wasting is a common complication of chronic heart failure (CHF) and linked to poor patient prognosis. In recent years, adiponectin was postulated to be centrally involved in CHF-associated metabolic failure and muscle wasting. This review discusses current knowledge on the role of adiponectin in CHF. Particular emphasis will be given to the complex interaction mechanisms and the intracellular pathways underlying adiponectin resistance in skeletal muscle of CHF patients. In this review, we propose that the resistance process is multifactorial, integrating abnormalities emanating from insulin signalling, mitochondrial biogenesis, and ceramide metabolism.
E-info
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http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379868200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Full text (open access)
https://repository.uantwerpen.be/docman/irua/239951/134975.pdf
Handle