Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score
Faculty of Medicine and Health Sciences
Journal of diabetes and its complications. - New York
, p. 1043-1049
University of Antwerp
Aim: To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status. Methods: In 651 overweight/obese subjects (M/F: 193/458, age 43 +/- 13 y, BMI 38.2 +/- 6.1 kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and subcutaneous fat (SAT) were examined. Results: Exactly 50.4% were found to have prediabetes and 11.1% were newly diagnosed with type 2 diabetes (T2DM) (M/F = 22.2/8.8%). Subjects without T2DM had a FINDRISC score of 11 +/- 3, those with pre-DM 13 +/- 4, and subjects with de novo T2DM 15 +/- 5. The aROC of the FINDRISC for detecting T2DM was 0.76 (95% CI 0.72-0.82), with 13 as cutoff point. The FINDRISC score correlated with VAT (r = 0.34, p < 0.001) and VAT/SAT ratio (r = 0.39, p < 0.001). The aROC of the FINDRISC to detect excess VAT was 0.79 (95%CI 0.72-0.84). Conclusions: In a large group of overweight and obese subjects, 50.4% were found to have pre-DM and 11.1% were newly diagnosed with T2DM. The FINDRISC score increased with worsening of glucose tolerance status and proved to be an independent predictor of T2DM status, as did HOMA-B, HOMA-S and VAT. The FINDRISC can also function as a good tool to predict visceral obesity. (C) 2016 Elsevier Inc. All rights reserved.