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Title
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Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score
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Author
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Abstract
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| Aim: To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status. Methods: In 651 overweight/obese subjects (M/F: 193/458, age 43 +/- 13 y, BMI 38.2 +/- 6.1 kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and subcutaneous fat (SAT) were examined. Results: Exactly 50.4% were found to have prediabetes and 11.1% were newly diagnosed with type 2 diabetes (T2DM) (M/F = 22.2/8.8%). Subjects without T2DM had a FINDRISC score of 11 +/- 3, those with pre-DM 13 +/- 4, and subjects with de novo T2DM 15 +/- 5. The aROC of the FINDRISC for detecting T2DM was 0.76 (95% CI 0.72-0.82), with 13 as cutoff point. The FINDRISC score correlated with VAT (r = 0.34, p < 0.001) and VAT/SAT ratio (r = 0.39, p < 0.001). The aROC of the FINDRISC to detect excess VAT was 0.79 (95%CI 0.72-0.84). Conclusions: In a large group of overweight and obese subjects, 50.4% were found to have pre-DM and 11.1% were newly diagnosed with T2DM. The FINDRISC score increased with worsening of glucose tolerance status and proved to be an independent predictor of T2DM status, as did HOMA-B, HOMA-S and VAT. The FINDRISC can also function as a good tool to predict visceral obesity. (C) 2016 Elsevier Inc. All rights reserved. |
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Language
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English
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Source (journal)
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Journal of diabetes and its complications. - New York
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Publication
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New York
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2016
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ISSN
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1056-8727
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DOI
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10.1016/J.JDIACOMP.2016.05.004
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Volume/pages
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30
:6
(2016)
, p. 1043-1049
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ISI
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000380579000011
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Pubmed ID
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27217020
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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