Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC scoreScreening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score
Faculty of Medicine and Health Sciences
Laboratory Experimental Medicine and Pediatrics (LEMP)
2016New York, 2016
Journal of diabetes and its complications. - New York
30(2016):6, p. 1043-1049
University of Antwerp
Aim: To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status. Methods: In 651 overweight/obese subjects (M/F: 193/458, age 43 +/- 13 y, BMI 38.2 +/- 6.1 kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and subcutaneous fat (SAT) were examined. Results: Exactly 50.4% were found to have prediabetes and 11.1% were newly diagnosed with type 2 diabetes (T2DM) (M/F = 22.2/8.8%). Subjects without T2DM had a FINDRISC score of 11 +/- 3, those with pre-DM 13 +/- 4, and subjects with de novo T2DM 15 +/- 5. The aROC of the FINDRISC for detecting T2DM was 0.76 (95% CI 0.72-0.82), with 13 as cutoff point. The FINDRISC score correlated with VAT (r = 0.34, p < 0.001) and VAT/SAT ratio (r = 0.39, p < 0.001). The aROC of the FINDRISC to detect excess VAT was 0.79 (95%CI 0.72-0.84). Conclusions: In a large group of overweight and obese subjects, 50.4% were found to have pre-DM and 11.1% were newly diagnosed with T2DM. The FINDRISC score increased with worsening of glucose tolerance status and proved to be an independent predictor of T2DM status, as did HOMA-B, HOMA-S and VAT. The FINDRISC can also function as a good tool to predict visceral obesity. (C) 2016 Elsevier Inc. All rights reserved.