Title
Cyclopeptide alkaloids from Hymenocardia acida Cyclopeptide alkaloids from Hymenocardia acida
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Columbus, Ohio ,
Subject
Biology
Pharmacology. Therapy
Source (journal)
Journal of natural products. - Columbus, Ohio, 1979, currens
Volume/pages
79(2016) :7 , p. 1746-1751
ISSN
0163-3864
ISI
000380422400006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Four cyclopeptide alkaloids (1-4) were isolated from the root bark of Hymenocardia acida by means of semipreparative HPLC with DAD and ESIMS detection and conventional separation methods. Structure elucidation was performed by spectroscopic means. In addition to the known compound hymenocardine (1), three other alkaloids were isolated for the first time from a natural source. These included a hymenocardine derivative with a hydroxy group instead of a carbonyl group that was named hymenocardinol (2), as well as hymenocardine N-oxide (3) and a new cyclopeptide alkaloid containing an unusual histidine moiety named hymenocardine-H (4). The isolated cyclopeptide alkaloids were tested for their antiplasmodial activity and cytotoxicity. All four compounds showed moderate antiplasmodial activity, with IC50 values ranging from 12.2 to 27.9 mu M, the most active one being hymenocardine N-oxide (3), with an IC50 value of 12.2 +/- 6.6 mu M. Compounds 2-4 were found not to be cytotoxic against MRC-5 cells (IC50 > 64.0 mu M), but hymenocardine (1) showed some cytotoxicity, with an IC50 value of 51.1 +/- 17.2 mu M.
E-info
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https://repository.uantwerpen.be/docman/iruaauth/e461c5/135030.pdf
Handle