Title
Evaluation and consequences of heterogeneity in the circulating tumor cell compartment Evaluation and consequences of heterogeneity in the circulating tumor cell compartment
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Albany :Impact journals llc ,
Subject
Biology
Human medicine
Source (journal)
Oncotarget. - Albany, N.Y, 2010, currens
Volume/pages
7(2016) :30 , p. 48625-48643
ISSN
1949-2553
ISI
000385413000140
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A growing understanding of the molecular biology of cancer and the identification of specific aberrations driving cancer evolution have led to the development of various targeted agents. Therapeutic decisions concerning these drugs are often guided by single biopsies of the primary tumor. Yet, it is well known that tumors can exhibit significant heterogeneity and change over time as a result of selective pressure. Circulating tumor cells (CTCs) are shed from various tumor sites and are thought to represent the molecular landscape of a patients overall tumor burden. Moreover, a minimal-invasive liquid biopsy facilitates monitoring of clonal evolution during therapy pressure and disease progression in real-time. While more information becomes available regarding heterogeneity among CTCs, comparison between these studies is needed. In this review, we focus on the genomic and transcriptional heterogeneity found in the CTC compartment, and its significance for clinical decision making.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/7710fd/135245.pdf
Handle