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Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers
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Author
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Abstract
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Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients. METHODS: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes. RESULTS: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort. CONCLUSIONS: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC. |
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Language
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English
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Source (journal)
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Breast cancer research / National Library of Medicine (U.S.); National Center for Biotechnology Information (U.S.) - London, 1999, currens
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Publication
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London
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BioMed Central Ltd
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2013
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ISSN
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1465-542X
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DOI
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10.1186/BCR3579
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Volume/pages
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15
:6
(2013)
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Article Reference
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R112
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ISI
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000331544200009
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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