Publication
Title
Mechanisms of tumour vascularization in cutaneous malignant melanoma : clinical implications
Author
Abstract
Malignant melanoma represents < 10% of all skin cancers but is responsible for the majority of skin-cancer-related deaths. Metastatic melanoma has historically been considered as one of the most therapeutically challenging malignancies. Fortunately, for the first time after decades of basic research and clinical investigation, new drugs have produced major clinical responses. Angiogenesis has been considered an important target for cancer treatment. Initial efforts have focused primarily on targeting endothelial and tumour-related vascular endothelial growth factor signalling. Here, we review different mechanisms of tumour vascularization described in melanoma and discuss the potential clinical implications.
Language
English
Source (journal)
British journal of dermatology. - Oxford
Publication
Oxford : 2014
ISSN
0007-0963
Volume/pages
171:2(2014), p. 220-233
ISI
000344005200006
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 15.09.2016
Last edited 15.06.2017