Title
Mechanisms of tumour vascularization in cutaneous malignant melanoma : clinical implications Mechanisms of tumour vascularization in cutaneous malignant melanoma : clinical implications
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford ,
Subject
Human medicine
Source (journal)
British journal of dermatology. - Oxford
Volume/pages
171(2014) :2 , p. 220-233
ISSN
0007-0963
ISI
000344005200006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Malignant melanoma represents < 10% of all skin cancers but is responsible for the majority of skin-cancer-related deaths. Metastatic melanoma has historically been considered as one of the most therapeutically challenging malignancies. Fortunately, for the first time after decades of basic research and clinical investigation, new drugs have produced major clinical responses. Angiogenesis has been considered an important target for cancer treatment. Initial efforts have focused primarily on targeting endothelial and tumour-related vascular endothelial growth factor signalling. Here, we review different mechanisms of tumour vascularization described in melanoma and discuss the potential clinical implications.
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