Title
Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition
Author
Faculty/Department
Faculty of Sciences. Chemistry
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Oxford ,
Subject
Pharmacology. Therapy
Source (journal)
Bioorganic and medicinal chemistry letters. - Oxford
Volume/pages
26(2016) :20 , p. 5032-5038
ISSN
0960-894X
ISI
000385498500036
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The synthesis and in vitro properties of six analogues of the selective glucocorticoid receptor (GR) agonist GSK866, bearing a warhead for covalent linkage to the glucocorticoid receptor, is described.
E-info
https://repository.uantwerpen.be/docman/iruaauth/35393e/135401.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/6b54ca/135401.pdf
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Handle