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Title
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Antiprotozoal and antiglycation activities of sesquiterpene coumarins from Ferula narthex exudate
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Author
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Abstract
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| The exudate of Ferula narthex Boiss. (Apiaceae) is widely used in the Indian subcontinent as a spice and because of its health effects. Six sesquiterpene coumarins have been isolated from this exudate: feselol, ligupersin A, asacoumarin A, 8′-O-acetyl-asacoumarin A, 10′R-karatavacinol and 10′R-acetyl-karatavacinol. Based on its use in infectious and diabetic conditions, the isolated constituents were evaluated for antimicrobial and antiglycation activities. Some compounds showed activity against protozoal parasites, asacoumarin A being the most active one against Plasmodium falciparum K1 (IC50 1.3 μM). With regard to antiglycation activity, in the BSA-glucose test, ligupersin A displayed the highest activity (IC50 0.41 mM), being more active than the positive control aminiguanidine (IC50 1.75 mM). In the BSA-MGO assay, the highest activity was shown by 8′-O-acetyl-asacoumarin A (IC50 1.03 mM), being less active than aminoguanidine (IC50 0.15 mM). Hence, the antiglycation activity of the isolated constituents was due to both oxidative and non-oxidative modes of inhibition. |
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Language
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English
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Source (journal)
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Molecules: a journal of synthetic chemistry and natural product chemistry. - Bazel
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Publication
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Bazel
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2016
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ISSN
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1420-3049
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DOI
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10.3390/MOLECULES21101287
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Volume/pages
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21
:10
(2016)
, 10 p.
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Article Reference
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1287
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ISI
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000389917900024
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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