Antiprotozoal and antiglycation activities of sesquiterpene coumarins from Ferula narthex exudateAntiprotozoal and antiglycation activities of sesquiterpene coumarins from Ferula narthex exudate
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Natural Products and Food - Research and Analysis (NatuRA)
Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
Molecules: a journal of synthetic chemistry and natural product chemistry. - Bazel
21(2016):10, p. 1-10
University of Antwerp
The exudate of Ferula narthex Boiss. (Apiaceae) is widely used in the Indian subcontinent as a spice and because of its health effects. Six sesquiterpene coumarins have been isolated from this exudate: feselol, ligupersin A, asacoumarin A, 8′-O-acetyl-asacoumarin A, 10′R-karatavacinol and 10′R-acetyl-karatavacinol. Based on its use in infectious and diabetic conditions, the isolated constituents were evaluated for antimicrobial and antiglycation activities. Some compounds showed activity against protozoal parasites, asacoumarin A being the most active one against Plasmodium falciparum K1 (IC50 1.3 μM). With regard to antiglycation activity, in the BSA-glucose test, ligupersin A displayed the highest activity (IC50 0.41 mM), being more active than the positive control aminiguanidine (IC50 1.75 mM). In the BSA-MGO assay, the highest activity was shown by 8′-O-acetyl-asacoumarin A (IC50 1.03 mM), being less active than aminoguanidine (IC50 0.15 mM). Hence, the antiglycation activity of the isolated constituents was due to both oxidative and non-oxidative modes of inhibition.