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Title
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CD70 expression and its correlation with clinicopathological variables in squamous cell carcinoma of the head and neck
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Author
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Abstract
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| Objective: Over the last decade, efforts have been made to get a better understanding of the tumor microenvironment and the role of the immune system in it. New insights into the CD27/CD70 signaling pathway point towards a role in tumor immunology, making CD70 an attractive target for immunotherapy. Here, we evaluate CD70 expression in squamous cell carcinoma of the head and neck (SCCHN). Methods: CD70 immunohistochemistry was retrospectively performed on 95 tumor samples. Tumoral CD70 expression was scored and correlated with clinicopathological variables and overall survival (OS). Results: CD70 expression in tumor cells was observed in 66 samples (69%) and was strongly associated with tumor differentiation grade (p < 0.001). CD70 expression was also observed in tumor-associated fibroblasts and endothelial cells. Additionally, the density of tumor-infiltrating lymphocytes correlated with OS (p = 0.042). Conclusion: This study describes the tumoral expression of CD70 in SCCHN. Results highlight the role of CD70 in tumor biology and identify CD70 as a novel therapeutic target. Further research is warranted. (C) 2016 S. Karger AG, Basel |
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Language
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English
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Source (journal)
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Pathobiology. - Basel, 1990, currens
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Publication
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Basel
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S. Karger
,
2016
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ISSN
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1015-2008
[print]
1423-0291
[online]
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DOI
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10.1159/000446569
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Volume/pages
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83
:6
(2016)
, p. 327-333
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ISI
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000381243700007
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Pubmed ID
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27389010
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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