|
Title
|
|
|
|
Liver fibrosis evaluation using real-time shear wave elastography in hepatitis C-monoinfected and human immunodeficiency virus/hepatitis C-coinfected patients
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Objectives-A few studies have evaluated real-time shear wave elastography (SWE) for assessing liver fibrosis by measuring liver stiffness in patients with chronic hepatitis C virus (HCV) infection, but they excluded human immunodeficiency virus/HCV-coinfected patients. We investigated the diagnostic performance of liver stiffness measured by SWE as a noninvasive predictor of liver fibrosis in HCV using liver biopsy as a reference standard, including monoinfected and coinfected patients. Methods-We measured liver stiffness in patients with HCV undergoing liver biopsy (METAVIR fibrosis staging). Results-Eighty patients (53 monoinfected and 27 coinfected) were included. There was a significant correlation between liver stiffness and fibrosis stage (rho = 0.685; P < .001). Areas under the receiver operating characteristic curve were 0.841, 0.879, and 0.975 when comparing fibrosis stages F0-F1 versus F2-F4, F0-F2 versus F3-F4, and F0-F3 versus F4, respectively. Suggested cutoff values were 8.5 kPa for F2, 10.4 kPa for F3, and 11.3 kPa for F4, with sensitivity and specificity of 81% and 84%, 81% and 95%, and 100% and 90%. There was no significant difference between the liver stiffness of monoinfected and coinfected patients (P = .453). When combining SWE with the fibrosis-4 score, accuracy increased from 82% to 88% and from 88% to 96%, with incongruent results of 26% and 29%, for F0-F1 versus F2-F4 and F0-F2 versus F3-F4. Conclusions-Shear wave elastography of the liver is an effective noninvasive predictor of liver fibrosis in patients with HCV. There was no significant difference between monoinfected and coinfected patients; hence, the same cutoff values can be used for both groups. Combination of SWE with the fibrosis-4 score leads to higher accuracy, although at the expense of inconclusive results in some patients. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Journal of ultrasound in medicine. - Rockville, Md, 1982, currens
| |
|
Publication
|
|
|
|
Rockville, Md
:
2016
| |
|
ISSN
|
|
|
|
0278-4297
[print]
1550-9613
[online]
| |
|
DOI
|
|
|
|
10.7863/ULTRA.15.08066
| |
|
Volume/pages
|
|
|
|
35
:6
(2016)
, p. 1299-1308
| |
|
ISI
|
|
|
|
000382504100021
| |
|
Pubmed ID
|
|
|
|
27151906
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (publisher's version - intranet only)
|
|
|
|
| |
|