Publication
Title
Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the pore
Author
Abstract
The marine polycyclic-ether toxin gambierol and 1-butanol (n-alkanol) inhibit Shaker-type Kv channels by interfering with the gating machinery. Competition experiments indicated that both compounds do not share an overlapping binding site but gambierol is able to affect 1-butanol affinity for Shaker through an allosteric effect. Furthermore, the Shaker-P475A mutant, which inverses 1-butanol effect, is inhibited by gambierol with nM affinity. Thus, gambierol and 1-butanol inhibit Shaker-type Kv channels via distinct parts of the gating machinery.
Language
Dutch, English
Source (journal)
Toxicon. - Oxford
Publication
Oxford : 2016
ISSN
0041-0101
Volume/pages
120(2016), p. 57-60
ISI
000383824100009
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 06.10.2016
Last edited 09.06.2017
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