Publication
Title
Neutrophil gelatinase-associated lipocalin and its receptors in Alzheimers disease (AD) brain regions : differential findings in AD with and without depression
Author
Abstract
Co-existing depression worsens Alzheimers disease (AD) pathology. Neutrophil gelatinase-associated lipocalin (NGAL) is a newly identified (neuro)inflammatory mediator in the pathophysiologies of both AD and depression. This study aimed to compare NGAL levels in healthy controls, AD without depression (ADD), and AD with co-existing depression (AD+D) patients. Protein levels of NGAL and its receptors, 24p3R and megalin, were assessed in nine brain regions from healthy controls (n = 19), ADD (n = 19), and AD+D (n = 21) patients. NGAL levels in ADD patients were significantly increased in brain regions commonly associated with AD. In the hippocampus, NGAL levels were even further increased in AD+D subjects. Unexpectedly, NGAL levels in the prefrontal cortex of AD+D patients were comparable to those in controls. Megalin levels were increased in BA11 and amygdala of AD+D patients, while no changes in 24p3R were detected. These findings indicate significant differences in neuroimmunological regulation between AD patients with and without co-existing depression. Considering its known effects, elevated NGAL levels might actively promote neuropathological processes in AD with and without depression.
Language
English
Source (journal)
Journal of Alzheimer's disease
Publication
2017
ISSN
1387-2877
Volume/pages
55:2(2017), p. 763-776
ISI
000389695700028
Full text (Publishers DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 11.10.2016
Last edited 08.05.2017
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