|
Title
|
|
|
|
Analysis of diagnostic findings from the European Mobile Laboratory in Guéckédou, Guinea, march 2014 through march 2015
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Background. A unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease (EVD) treatment unit in Guéckédou, Guinea, from March 2014 through March 2015. Methods. The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcriptionpolymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively. Results. The cleaned EMLab database comprised 4719 samples from 2741 cases of suspected EVD from Guinea. EVD was diagnosed in 1231 of 2178 hospitalized patients (57%) and in 281 of 563 who died in the community (50%). Children aged <15 years had the highest proportion of Ebola virusmalaria parasite coinfections. The case-fatality ratio was high in patients aged <5 years (80%) and those aged >74 years (90%) and low in patients aged 1019 years (40%). On admission, RT-PCR analysis of blood specimens from patients who died in the hospital yielded a lower median cycle threshold (Ct) than analysis of blood specimens from survivors (18.1 vs 23.2). Individuals who died in the community had a median Ct of 21.5 for throat swabs. Multivariate logistic regression on 1047 data sets revealed that low Ct values, ages of <5 and ≥45 years, and, among children aged 514 years, malaria parasite coinfection were independent determinants of a poor EVD outcome. Conclusions. Virus load, age, and malaria parasite coinfection play a role in the outcome of EVD. |
| |
|
Language
|
|
|
|
Dutch, English
| |
|
Source (journal)
|
|
|
|
The journal of infectious diseases. - Chicago, Ill.
| |
|
Publication
|
|
|
|
Chicago, Ill.
:
2016
| |
|
ISSN
|
|
|
|
0022-1899
| |
|
DOI
|
|
|
|
10.1093/INFDIS/JIW269
| |
|
Volume/pages
|
|
|
|
214
:s:[3]
(2016)
, p. S250-S257
| |
|
ISI
|
|
|
|
000386148800021
| |
|
Pubmed ID
|
|
|
|
27638946
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (open access)
|
|
|
|
| |
|