Publication
Title
Patient, treatment, and anatomical predictors of outcome in electroconvulsive therapy : a prospective study
Author
Abstract
Objectives: Baseline predictors of effectiveness and cognitive adverse effects of electroconvulsive therapy (ECT) were prospectively examined. Methods: Before and after ECT, the Montgomery-Asberg Depression Rating Scale (MADRS) and Mini Mental State Examination (MMSE) were assessed. Before ECT, a magnetic resonance imaging of the head was performed. Outcome predictors were investigated using multivariable regression analyses. Results: Of 83 patients (mean +/- SD age, 59.2 +/- 15.3 years; 39% men), 28% had a psychotic depressive disorder, 16% had a bipolar depression, 30% had had previous ECT course(s), and 66% used concomitant antipsychotics. Presence of psychotic depression (beta = -0.25; P = 0.04) and having had previous ECT (beta = -0.35; P = 0.003) predicted lower post-ECTMADRS score. Baseline magnetic resonance imaging characteristics were not predictive of post-ECT MADRS and MMSE scores. The use of concomitant antipsychotics predicted a lower post-ECT MMSE score (beta = -0.21; P = 0.02), whereas the presence of bipolar depression at baseline predicted higher post-ECTMMSE score (beta = 0.23; P = 0.01). The post-ECT MADRS score seemed to be a confounder for the post-ECT MMSE score (beta = -0.20; P = 0.02). Conclusions: Effectiveness of ECT was better in the patients with a baseline psychotic depression and those who had had ECT before. Cognitive outcome was better in the patients with baseline bipolar depression but worse in those who used antipsychotics during ECT and those who showed more persistent depressive symptoms after ECT.
Language
English
Source (journal)
Journal of ECT. - Place of publication unknown
Publication
Place of publication unknown : 2013
ISSN
1095-0680
DOI
10.1097/YCT.0B013E31827E0D02
Volume/pages
29 :2 (2013) , p. 113-121
ISI
000319457700017
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 17.11.2016
Last edited 16.02.2023
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